Yasir Arfat

Yasir Arfat

PhD. Student at Computer Science Department, University of Turin
Parallel Computing group
Via Pessinetto 12, 10149 Torino – Italy
Email: yasir.arfat@unito.it

Yasir Arfat from Kashmir, Pakistan is a holder of BS degree in Software Engineering from University of Azad Jammu & Kashmir, Muzaffarabad, Pakistan, 2011 and MSc degree in computer science from King Abdulaziz University, Jeddah, Saudi Arabia, 2017. Now, he is currently pursuing his PhD degree from the University of Turin (Unito). He was awarded “Shining Star” for his excellent performance in 2009 and was a “Gold Medallist” for highest CGPA in bachelor degree.
He has four-year experience in software development. He was a software engineer with ActiveXoft and Lambda Technologies, Lahore from 2011-2014 and an iOS Mobile application developer with Dunay TV, Lahore from 2014 to 2015. He also has two years of research experience, working at high-performance computer centre (HPCC) KAU.

His main areas of interest are data analytics, distributed and parallel computing, machine learning, data science and software engineering.

Publications

2021

  • F. D’Ascenzo, O. De Filippo, G. Gallone, G. Mittone, M. A. Deriu, M. Iannaccone, A. Ariza-Solé, C. Liebetrau, S. Manzano-Fernández, G. Quadri, T. Kinnaird, G. Campo, J. P. Simao Henriques, J. M. Hughes, A. Dominguez-Rodriguez, M. Aldinucci, U. Morbiducci, G. Patti, S. Raposeiras-Roubin, E. Abu-Assi, G. M. De Ferrari, F. Piroli, A. Saglietto, F. Conrotto, P. Omedé, A. Montefusco, M. Pennone, F. Bruno, P. P. Bocchino, G. Boccuzzi, E. Cerrato, F. Varbella, M. Sperti, S. B. Wilton, L. Velicki, I. Xanthopoulou, A. Cequier, A. Iniguez-Romo, I. Munoz Pousa, M. Cespon Fernandez, B. Caneiro Queija, R. Cobas-Paz, A. Lopez-Cuenca, A. Garay, P. F. Blanco, A. Rognoni, G. Biondi Zoccai, S. Biscaglia, I. Nunez-Gil, T. Fujii, A. Durante, X. Song, T. Kawaji, D. Alexopoulos, Z. Huczek, J. R. Gonzalez Juanatey, S. Nie, M. Kawashiri, I. Colonnelli, B. Cantalupo, R. Esposito, S. Leonardi, W. Grosso Marra, A. Chieffo, U. Michelucci, D. Piga, M. Malavolta, S. Gili, M. Mennuni, C. Montalto, L. Oltrona Visconti, and Y. Arfat, “Machine learning-based prediction of adverse events following an acute coronary syndrome (PRAISE): a modelling study of pooled datasets,” The lancet, vol. 397, iss. 10270, pp. 199-207, 2021. doi:10.1016/S0140-6736(20)32519-8
    [BibTeX] [Abstract] [Download PDF]

    Background The accuracy of current prediction tools for ischaemic and bleeding events after an acute coronary syndrome (ACS) remains insufficient for individualised patient management strategies. We developed a machine learning-based risk stratification model to predict all-cause death, recurrent acute myocardial infarction, and major bleeding after ACS. Methods Different machine learning models for the prediction of 1-year post-discharge all-cause death, myocardial infarction, and major bleeding (defined as Bleeding Academic Research Consortium type 3 or 5) were trained on a cohort of 19826 adult patients with ACS (split into a training cohort [80%] and internal validation cohort [20%]) from the BleeMACS and RENAMI registries, which included patients across several continents. 25 clinical features routinely assessed at discharge were used to inform the models. The best-performing model for each study outcome (the PRAISE score) was tested in an external validation cohort of 3444 patients with ACS pooled from a randomised controlled trial and three prospective registries. Model performance was assessed according to a range of learning metrics including area under the receiver operating characteristic curve (AUC). Findings The PRAISE score showed an AUC of 0.82 (95% CI 0.78-0.85) in the internal validation cohort and 0.92 (0.90-0.93) in the external validation cohort for 1-year all-cause death; an AUC of 0.74 (0.70-0.78) in the internal validation cohort and 0.81 (0.76-0.85) in the external validation cohort for 1-year myocardial infarction; and an AUC of 0.70 (0.66-0.75) in the internal validation cohort and 0.86 (0.82-0.89) in the external validation cohort for 1-year major bleeding. Interpretation A machine learning-based approach for the identification of predictors of events after an ACS is feasible and effective. The PRAISE score showed accurate discriminative capabilities for the prediction of all-cause death, myocardial infarction, and major bleeding, and might be useful to guide clinical decision making.

    @article{21:lancet,
    abstract = {Background The accuracy of current prediction tools for ischaemic and bleeding events after an acute coronary syndrome (ACS) remains insufficient for individualised patient management strategies. We developed a machine learning-based risk stratification model to predict all-cause death, recurrent acute myocardial infarction, and major bleeding after ACS.
    Methods Different machine learning models for the prediction of 1-year post-discharge all-cause death, myocardial infarction, and major bleeding (defined as Bleeding Academic Research Consortium type 3 or 5) were trained on a cohort of 19826 adult patients with ACS (split into a training cohort [80%] and internal validation cohort [20%]) from the BleeMACS and RENAMI registries, which included patients across several continents. 25 clinical features routinely assessed at discharge were used to inform the models. The best-performing model for each study outcome (the PRAISE score) was tested in an external validation cohort of 3444 patients with ACS pooled from a randomised controlled trial and three prospective registries. Model performance was assessed according to a range of learning metrics including area under the receiver operating characteristic curve (AUC).
    Findings The PRAISE score showed an AUC of 0.82 (95% CI 0.78-0.85) in the internal validation cohort and 0.92 (0.90-0.93) in the external validation cohort for 1-year all-cause death; an AUC of 0.74 (0.70-0.78) in the internal validation cohort and 0.81 (0.76-0.85) in the external validation cohort for 1-year myocardial infarction; and an AUC of 0.70 (0.66-0.75) in the internal validation cohort and 0.86 (0.82-0.89) in the external validation cohort for 1-year major bleeding.
    Interpretation A machine learning-based approach for the identification of predictors of events after an ACS is feasible and effective. The PRAISE score showed accurate discriminative capabilities for the prediction of all-cause death, myocardial infarction, and major bleeding, and might be useful to guide clinical decision making.},
    author = {Fabrizio D'Ascenzo and Ovidio {De Filippo} and Guglielmo Gallone and Gianluca Mittone and Marco Agostino Deriu and Mario Iannaccone and Albert Ariza-Sol\'e and Christoph Liebetrau and Sergio Manzano-Fern\'andez and Giorgio Quadri and Tim Kinnaird and Gianluca Campo and Jose Paulo {Simao Henriques} and James M Hughes and Alberto Dominguez-Rodriguez and Marco Aldinucci and Umberto Morbiducci and Giuseppe Patti and Sergio Raposeiras-Roubin and Emad Abu-Assi and Gaetano Maria {De Ferrari} and Francesco Piroli and Andrea Saglietto and Federico Conrotto and Pierluigi Omed\'e and Antonio Montefusco and Mauro Pennone and Francesco Bruno and Pier Paolo Bocchino and Giacomo Boccuzzi and Enrico Cerrato and Ferdinando Varbella and Michela Sperti and Stephen B. Wilton and Lazar Velicki and Ioanna Xanthopoulou and Angel Cequier and Andres Iniguez-Romo and Isabel {Munoz Pousa} and Maria {Cespon Fernandez} and Berenice {Caneiro Queija} and Rafael Cobas-Paz and Angel Lopez-Cuenca and Alberto Garay and Pedro Flores Blanco and Andrea Rognoni and Giuseppe {Biondi Zoccai} and Simone Biscaglia and Ivan Nunez-Gil and Toshiharu Fujii and Alessandro Durante and Xiantao Song and Tetsuma Kawaji and Dimitrios Alexopoulos and Zenon Huczek and Jose Ramon {Gonzalez Juanatey} and Shao-Ping Nie and Masa-aki Kawashiri and Iacopo Colonnelli and Barbara Cantalupo and Roberto Esposito and Sergio Leonardi and Walter {Grosso Marra} and Alaide Chieffo and Umberto Michelucci and Dario Piga and Marta Malavolta and Sebastiano Gili and Marco Mennuni and Claudio Montalto and Luigi {Oltrona Visconti} and Yasir Arfat},
    date-modified = {2021-03-26 23:53:19 +0100},
    doi = {10.1016/S0140-6736(20)32519-8},
    issn = {0140-6736},
    journal = {The Lancet},
    keywords = {deephealth, hpc4ai},
    number = {10270},
    pages = {199-207},
    title = {Machine learning-based prediction of adverse events following an acute coronary syndrome {(PRAISE)}: a modelling study of pooled datasets},
    url = {https://www.researchgate.net/profile/James_Hughes3/publication/348501148_Machine_learning-based_prediction_of_adverse_events_following_an_acute_coronary_syndrome_PRAISE_a_modelling_study_of_pooled_datasets/links/6002a81ba6fdccdcb858b6c2/Machine-learning-based-prediction-of-adverse-events-following-an-acute-coronary-syndrome-PRAISE-a-modelling-study-of-pooled-datasets.pdf},
    volume = {397},
    year = {2021},
    bdsk-url-1 = {https://www.researchgate.net/profile/James_Hughes3/publication/348501148_Machine_learning-based_prediction_of_adverse_events_following_an_acute_coronary_syndrome_PRAISE_a_modelling_study_of_pooled_datasets/links/6002a81ba6fdccdcb858b6c2/Machine-learning-based-prediction-of-adverse-events-following-an-acute-coronary-syndrome-PRAISE-a-modelling-study-of-pooled-datasets.pdf},
    bdsk-url-2 = {https://doi.org/10.1016/S0140-6736(20)32519-8}
    }